Acetonitrile → 4-Cyano-N-(2-{7-[2-(2-fluoro-phenoxy)-ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}-ethyl)-N-methyl-benzenesulfonamide

関与物質

反応条件

反応手順

To 4-cyano-N-methyl-N-[2-(9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl)-ethyl]-benzenesulfonamide dihydrochloride (0.127 g, 0.30 mmol, prep I above), 1-(2-bromo-ethoxy)-2-fluoro-benzene (0.069 g, 0.315 mmol;) and potassium carbonate (0.145 g, 1.05 mmol) was added acetonitrile (4 mL) and water (0.1 mL). The mixture was heated by microwave irradiation (10 minutes, 160° C.) and was then filtered and evaporated. The crude product was purified by chromatography on silica gel using methanol saturated with ammonia in dichloromethane as eluent, which afforded 85 mg (58.0%) of the title compound.

情報源と証拠