化工社化工社 化学情報印刷レポート · 研究参考用
(3-Chlorophenyl)boronic acid → (4-Benzenesulfonyl-piperazin-1-yl)-[1-(3-chloro-phenyl)-5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3-Chlorophenyl)boronic acid | HCID 2734323 | — |
| 反応物 | (4-Benzenesulfonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone | HCID 68535846 | — |
| 生成物 | (4-Benzenesulfonyl-piperazin-1-yl)-[1-(3-chloro-phenyl)-5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone | HCID 24986571 | 47% |
反応手順
The title compound was synthesized in analogy to example 5, from (4-benzenesulfonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone (example 13) and 3-chlorophenylboronic acid to afford the desired product as a light brown foam (47%). MS (ISP): 634.3 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07648979B2 |
| 出典データセット | uspto-grants-2010_01 |
| ORD ID | ord-77a8acdb58bc4a6494adf821ff9b7fa7 |
| 出典メモ | uspto-grants-2010_01 |