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2-Chloropyridine-4-boronic acid → [1-(2-Chloro-pyridin-4-yl)-5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-[4-(propane-2-sulfonyl)-piperazin-1-yl]-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloropyridine-4-boronic acid | HCID 5151595 | — |
| 反応物 | [5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-[4-(propane-2-sulfonyl)-piperazin-1-yl]-methanone | HCID 68534115 | — |
| 生成物 | [1-(2-Chloro-pyridin-4-yl)-5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-[4-(propane-2-sulfonyl)-piperazin-1-yl]-methanone | HCID 86621930 | 41% |
反応手順
The title compound was synthesized in analogy to example 5, after stirring for 3.5 days at 35° C., from [5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-[4-(propane-2-sulfonyl)-piperazin-1-yl]-methanone (example 15) and 2-chloropyridine-4-boronic acid to afford the desired product as a light-brown foam (41%). MS (ISP): 601.4 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07648979B2 |
| 出典データセット | uspto-grants-2010_01 |
| ORD ID | ord-8d6302d5143a46ea917de2fb90dad450 |
| 出典メモ | uspto-grants-2010_01 |