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2-Chloropyridine-5-boronic acid → [1-(6-Chloro-pyridin-3-yl)-5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-cyclopropanesulfonyl-piperazin-1-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloropyridine-5-boronic acid | HCID 3845034 | — |
| 反応物 | (4-Cyclopropanesulfonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone | HCID 68535679 | — |
| 生成物 | [1-(6-Chloro-pyridin-3-yl)-5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-cyclopropanesulfonyl-piperazin-1-yl)-methanone | HCID 86621936 | 44% |
反応手順
The title compound was synthesized in analogy to example 5, from (4-cyclopropanesulfonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone (example 33) and 2-chloropyridine-5-boronic acid to afford the desired product as light brown foam (44%). MS (ISP): 599.4 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07648979B2 |
| 出典データセット | uspto-grants-2010_01 |
| ORD ID | ord-fa8cc329eec54398965db67e0f7cb1fb |
| 出典メモ | uspto-grants-2010_01 |