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Tetrahydro-4H-pyran-4-one → (4-Methanesulfonyl-piperazin-1-yl)-{5-[4-(tetrahydro-pyran-4-yl)-[1,4]diazepane-1-carbonyl]-1H-indol-2-yl}-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydro-4H-pyran-4-one | HCID 121599 | — |
| 反応物 | 4-[2-(4-methanesulfonyl-piperazine-1-carbonyl)-1H-indole-5-carbonyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester | HCID 68536747 | — |
| 生成物 | (4-Methanesulfonyl-piperazin-1-yl)-{5-[4-(tetrahydro-pyran-4-yl)-[1,4]diazepane-1-carbonyl]-1H-indol-2-yl}-methanone | HCID 68534110 | — |
反応手順
The title compound was synthesized in analogy to example 47, from 4-[2-(4-methanesulfonyl-piperazine-1-carbonyl)-1H-indole-5-carbonyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester and tetrahydro-4H-pyran-4-one. Yellow gum. MS (m/z): 518.3 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07648979B2 |
| 出典データセット | uspto-grants-2010_01 |
| ORD ID | ord-5ab03cfefd964cbabe49dab22e9a3bb2 |
| 出典メモ | uspto-grants-2010_01 |