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1-Methanesulfonylpiperazine hydrochloride → 4-[1-Isopropyl-2-(4-methanesulfonyl-piperazine-1-carbonyl)-1H-indole-5-carbonyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methanesulfonylpiperazine hydrochloride | HCID 16265612 | — |
| 反応物 | 5-(4-tert-butoxycarbonyl-[1,4]diazepane-1-carbonyl)-1-isopropyl-1H-indole-2-carboxylic acid | HCID 68538212 | — |
| 生成物 | 4-[1-Isopropyl-2-(4-methanesulfonyl-piperazine-1-carbonyl)-1H-indole-5-carbonyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester | HCID 68534006 | — |
反応手順
The title compound was synthesized in analogy to example 47a), from 5-(4-tert-butoxycarbonyl-[1,4]diazepane-1-carbonyl)-1-isopropyl-1H-indole-2-carboxylic acid and 1-methanesulfonyl-piperazine hydrochloride. White solid. MS (m/z): 576.4 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07648979B2 |
| 出典データセット | uspto-grants-2010_01 |
| ORD ID | ord-5507a1e3a2794383a3ced27c86528e9e |
| 出典メモ | uspto-grants-2010_01 |