N-[1-(6-Methoxy-[1,5]naphthyridin-4-yl)-pyrrolidin-3-yl]-N-methyl-acetamide → [1-(6-Methoxy-[1,5]naphthyridin-4-yl)-pyrrolidin-3-yl]-methyl-amine
反応式
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[N:13]1[CH2:17][CH2:16][CH:15]([N:18](C)[C:19](=O)C)[CH2:14]1>Cl>[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[N:13]1[CH2:17][CH2:16][CH:15]([NH:18][CH3:19])[CH2:14]1参加物
3
実験手順
N-[1-(6-Methoxy-[1,5]naphthyridin-4-yl)-pyrrolidin-3-yl]-N-methyl-acetamide (500 mg, 1.67 mmol) was suspended in 3N HCl (aq) and refluxed overnight. The solution was evaporated to dryness and azeotroped with acetonitrile to provide the title compound (1.2 g, 85%) as a white solid: LC-MS mlz 259 (M+H)+
後処理
- temperaturerefluxed overnight
- customThe solution was evaporated to dryness
- customazeotroped with acetonitrile
出典と根拠
- ORDレコード
- ord-c0e7ecad2c1949659529665b8506f0ad
- 出典データセット
- uspto-grants-2010_01
- 特許番号
- US07648984B2
反応ノート
読み込み中…