Hydrochloric Acid → (3S*,4R*)-4-(2,4-difluorophenyl)-1-ethylpyrrolidine-3-carboxylic acid hydrochloride
反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@@H:9]1[CH2:13][N:12]([CH2:14][CH3:15])[CH2:11][C@H:10]1[C:16]([O:18]C)=[O:17].[ClH:20]>>[ClH:20].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@@H:9]1[CH2:13][N:12]([CH2:14][CH3:15])[CH2:11][C@H:10]1[C:16]([OH:18])=[O:17]参加物
3
実験手順
Concentrated aqueous hydrochloric acid (10 ml) was added to methyl (3S,4R)-4-(2,4-difluorophenyl)-1-ethylpyrrolidine-3-carboxylate from Preparation 76 (500 mg, 1.85 mmol) and the resulting solution was stirred at room temperature for 16 hours. The reaction mixture was then evaporated to dryness in vacuo and the resultant residue was azeotroped with toluene (2×50 ml). This gave the title compound as an off-white foam, 500 mg.
後処理
- customThe reaction mixture was then evaporated to dryness in vacuo
- customthe resultant residue was azeotroped with toluene (2×50 ml)