Pyridinium chloride → 2-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenol

HRID 1993368ノート

反応式

HRID 1993368 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[N:11]=[N:12][C:13]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:14][CH:15]=2)[CH:5]=[CH:6][C:7]=1[O:8]C.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[N:11]=[N:12][C:13]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:14][CH:15]=2)[CH:5]=[CH:6][C:7]=1[OH:8]

参加物

3

反応物 2

HCID 10176127Pyridinium chlorideHCID 574454003-(3-Fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine

生成物 1

HCID 1360707052-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenol

反応条件

温度
170 °C

実験手順

A mixture of 3-(3-fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine (Step 1, 0.60 g, 2.0 mmol) and pyridine hydrochloride (3 g) was heated in an oil bath at 170° C. for 8 h. The sublimed pyridine hydrochloride on the top of the reaction flask was removed, and the residue (0.65 g) was used in the next step without further purification. MS (ESI pos. ion) m/z: 283.1 (M+H). Calc'd Exact Mass for C16H11FN2O2: 282.27.

後処理

  1. customThe sublimed pyridine hydrochloride on the top of the reaction flask was removed
  2. customthe residue (0.65 g) was used in the next step without further purification

出典と根拠

ORDレコード
ord-0e6be287f8ed412a89bbf6605cbdc0f7
出典データセット
uspto-grants-2010_01
特許番号
US07652009B2

反応ノート

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