Itaconic acid → 1-(3-Fluoro-4-methoxyphenyl)-5-oxopyrrolidine-3-carboxylic acid
反応式
[F:1][C:2]1[CH:3]=[C:4]([NH2:10])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[C:11]([OH:19])(=[O:18])[C:12]([CH2:14][C:15](O)=[O:16])=[CH2:13]>CO>[F:1][C:2]1[CH:3]=[C:4]([N:10]2[C:15](=[O:16])[CH2:14][CH:12]([C:11]([OH:19])=[O:18])[CH2:13]2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]参加物
4
反応条件
- 温度
- 110 °C
実験手順
A mixture of 3-fluoro-4-methoxybenzenamine (7.5 g, 0.053 mmol) and itaconic acid (6.9 g, 0.053 mmol) was heated to 110° C. for 2 h. The yellow solid was dissolved in 100 mL of MeOH and concentrated in vacuo. The resulting solid was washed with 50% EtOAc/hexanes to give the title compound as a light yellow solid. MS (ESI pos. ion) m/z: 254.2 (M+H). Calc'd Exact Mass for C12H12FNO4: 253.23.
後処理
- concentrationconcentrated in vacuo
- washThe resulting solid was washed with 50% EtOAc/hexanes
出典と根拠
- ORDレコード
- ord-e0ff7c67b1374d75be1e30dc1f87edb3
- 出典データセット
- uspto-grants-2010_01
- 特許番号
- US07652009B2
反応ノート
読み込み中…