4-Benzoyl-1-(3-fluoro-4-methoxyphenyl)pyrrolidin-2-one → 4-Benzoyl-1-(3-fluoro-4-hydroxyphenyl)pyrrolidin-2-one

HRID 1993386ノート

反応式

HRID 1993386 の反応式
[C:1]([CH:9]1[CH2:13][N:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20]C)=[C:16]([F:22])[CH:15]=2)[C:11](=[O:23])[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>B(Br)(Br)Br.C(Cl)Cl>[C:1]([CH:9]1[CH2:13][N:12]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([F:22])[CH:15]=2)[C:11](=[O:23])[CH2:10]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 574454054-Benzoyl-1-(3-fluoro-4-methoxyphenyl)pyrrolidin-2-one

生成物 1

HCID 574454064-Benzoyl-1-(3-fluoro-4-hydroxyphenyl)pyrrolidin-2-one

試薬・触媒・溶媒 1

HCID 22277759Boron tribromide dichloromethane溶媒

実験手順

A mixture of 4-benzoyl-1-(3-fluoro-4-methoxyphenyl)pyrrolidin-2-one (Step 2, 1.0 g, 3.2 mmol) in 20 mL of 1 M BBr3/CH2Cl2 was stirred at RT for 16 h. The solution was concentrated in vacuo and the residue was diluted with 50 mL of MeOH and concentrated in vacuo again. The resulting white solid was washed with 50% EtOAc/hexane to give the title compound. MS (ESI pos. ion) m/z: 300.4 (M+H). Calc'd Exact Mass for C17H14FNO3: 299.3.

後処理

  1. concentrationThe solution was concentrated in vacuo
  2. additionthe residue was diluted with 50 mL of MeOH
  3. concentrationconcentrated in vacuo again
  4. washThe resulting white solid was washed with 50% EtOAc/hexane

出典と根拠

ORDレコード
ord-7d0ece2889824c4d80fdf5d50a9d8af8
出典データセット
uspto-grants-2010_01
特許番号
US07652009B2

反応ノート

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