Hydrochloric Acid → HCID 68538445、化合物
反応式
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([O:15][C:16]2[CH:21]=[C:20]([N+:22]([O-:24])=[O:23])[CH:19]=[CH:18][N:17]=2)[CH2:11][CH2:10]1)=O)(C)(C)C>>[ClH:1].[ClH:1].[N+:22]([C:20]1[CH:19]=[CH:18][N:17]=[C:16]([O:15][CH:12]2[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]2)[CH:21]=1)([O-:24])=[O:23]参加物
3
実験手順
Add 8 mL of a 4 M solution of HCl in Et20 to 1.2 g of 4-(4-Nitro-pyridin-2-yloxy)-piperidine-1-carboxylic acid tert-butyl ester and stir the suspension for 4 hours. Evaporate the solvent and triturate the remaining solid with Et2O to afford 1.1 g of 4-nitro-2-(piperidin-4-yloxy)-pyridine dihydrochloride as a pale yellow solid (100% yield) (ES+(Q/z)=224 [M+H].
後処理
- customEvaporate the solvent
- customtriturate the remaining solid with Et2O
出典と根拠
- ORDレコード
- ord-43802b80952a4ad1b8b36ca9c02d86d9
- 出典データセット
- uspto-grants-2010_01
- 特許番号
- US07652015B2
反応ノート
読み込み中…