化工社化工社 化学情報印刷レポート · 研究参考用
4-Aminobenzoic Acid → Benzimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminobenzoic Acid | HCID 978 | — |
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | Cyanoacetamide | HCID 7898 | — |
| 反応物 | Thiophosgene | HCID 10040 | — |
| 反応物 | HCID 178418790 | HCID 178418790 | — |
| 生成物 | Benzimidazole | HCID 5798 | — |
| 生成物 | Benzothiazole | HCID 7222 | — |
| 生成物 | Benzenamine, 4-(2-benzoxazolyl)- | HCID 88733 | — |
| 生成物 | Thiocarbamoyl cyanoacetamide | HCID 13573014 | — |
反応手順
The 2-(4-aminophenyl)benzoxazole, benzothiazole, or benzimidazole was prepared by condensation of the appropriate aniline derivative with p-amino benzoic acid using polyphosphoric acid. The product was converted to the corresponding isothiocyanate with thiophosgene and subsequently condensed with cyanoacetamide to form the thiocarbamoyl cyanoacetamide. Treatment with bromine afforded the cyano hydroxy thiazole, which was converted to carboxamidine by treatment with the appropriate amide, as shown above.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07652047B2 |
| 出典データセット | uspto-grants-2010_01 |
| ORD ID | ord-acf9ff7ba07e412e9887c036d410a8b1 |
| 出典メモ | uspto-grants-2010_01 |