Methyl 4-nitro-2-(trifluoromethyl)benzoate → Methyl 4-amino-2-(trifluoromethyl)benzoate

HRID 1994124ノート

反応式

HRID 1994124 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([C:14]([F:17])([F:16])[F:15])[CH:5]=1)([O-])=O.O.O.[Sn](Cl)(Cl)(Cl)Cl>CCOC(C)=O>[NH2:1][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([C:14]([F:15])([F:16])[F:17])[CH:5]=1

参加物

4

反応物 2

HCID 46311176Methyl 4-nitro-2-(trifluoromethyl)benzoateHCID 85782573Tin tetrachloride dihydrate

生成物 1

HCID 46311081Methyl 4-amino-2-(trifluoromethyl)benzoate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Methyl 4-nitro-2-(trifluoromethyl)benzoate (5.20 g, 20.9 mmol) was dissolved in EtOAc (100 mL) and tin chloride dihydrate (9.41 g, 41.7 mmol) was added to the reaction mixture. The reaction was heated at reflux for 2 h. The crude reaction mixture was purified by column chromatography (SiO2, EtOAc/hexanes) to give the title compound. LCMS: (FA) ES− 218.4 (M−1).

後処理

  1. temperatureThe reaction was heated
  2. temperatureat reflux for 2 h
  3. customThe crude reaction mixture
  4. customwas purified by column chromatography (SiO2, EtOAc/hexanes)

出典と根拠

ORDレコード
ord-5142fc929ec341fcbdd87482b31c9991
出典データセット
uspto-grants-2010_01
特許番号
US07652041B2

反応ノート

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