Water → HCID 22266530、化合物
反応式
Cl.N1C=CC=CC=1.[CH2:8]([N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18]C)[C:13]1=[S:20])[CH2:9][CH2:10][CH3:11].O>C(OCC)(=O)C>[CH2:8]([N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[C:13]1=[S:20])[CH2:9][CH2:10][CH3:11]参加物
5
反応条件
- 温度
- 190 °C
実験手順
Pyridine hydrochloride salt (3.6 g) was added to 1-butyl-3-methoxypyridine-2-thione (2-034-03) (1.4 g), and the reaction mixture was stirred at 190° C. for 40 min. To the reaction mixture were added water and ethyl acetate, and the organic layer was separated, and the organic layer was extracted three times with ethyl acetate. The combined organic layers were washed with water and brine, dried over anhydrous magnesium sulfate, and evaporated under reduced pressure to give 1-butyl-3-hydroxypyridine-2-thione (2-034-04) (1.02 g, 0.78%) as an oil.
後処理
- customthe organic layer was separated
- extractionthe organic layer was extracted three times with ethyl acetate
- washThe combined organic layers were washed with water and brine
- dry with materialdried over anhydrous magnesium sulfate
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-d08b60b86298443bae040229078fa4ed
- 出典データセット
- uspto-grants-2010_01
- 特許番号
- US07652141B2
反応ノート
読み込み中…