Phosphorus oxychloride → 2-chloro-3-phenylpyrazine
反応式
[C:1]1([C:7]2[C:8](=O)[NH:9][CH:10]=[CH:11][N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)([Cl:16])=O>>[Cl:16][C:8]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:12][CH:11]=[CH:10][N:9]=1参加物
3
実験手順
A 0.01 mol. sample of 3-phenylpyrazin-2(1H)one is mixed with 9.0 ml. of phosphorous oxychloride (POCl3) and refluxed for 5-6 hr. The excess phosphorous oxychloride is removed by distillation at reduced pressure and 25 ml. of methylene chloride added to the residue. The resultant solution is stirred with a few milliliters of ice water, dried, evaporated and the residue recrystallized to yield the title compound.
後処理
- customThe excess phosphorous oxychloride is removed by distillation at reduced pressure and 25 ml
- additionof methylene chloride added to the residue
- customdried
- customevaporated
- customthe residue recrystallized
出典と根拠
- ORDレコード
- ord-370af20a5193473586928eff3cc9b7e5
- 出典データセット
- uspto-grants-1983_09
- 特許番号
- US04402958
反応ノート
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