Sulfuric Acid → 2-Chloro-5-phenylpyrazine

HRID 1995060

反応式

HRID 1995060 の反応式
[C:1]1([C:7]2[N:8]=[CH:9][C:10](=O)[NH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O=P(Cl)(Cl)[Cl:16].S(=O)(=O)(O)O>>[Cl:16][C:10]1[CH:9]=[N:8][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:12][N:11]=1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 24813Phosphorus oxychlorideHCID 5990375-phenyl-1H-pyrazin-2-one

生成物 1

HCID 12366642-Chloro-5-phenylpyrazine

実験手順

A mixture of 0.01 mol. of 5-phenylpyrazin-2(1H)one 8.0 ml. of POCl3 and a drop of concentrated sulfuric acid is refluxed for 4-5 hr. The solution is poured into 100 g. of ice. The title compound is isolated by filtration and recrystallized.

後処理

  1. additionA mixture of 0.01 mol
  2. additionThe solution is poured into 100 g

出典と根拠

ORDレコード
ord-2130e3284caf45838b838060e626ad40
出典データセット
uspto-grants-1983_09
特許番号
US04402958

関連ノート

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