2,5-Dimethoxytetrahydrofuran → HCID 70532416、化合物

HRID 1995322ノート

反応式

HRID 1995322 の反応式
[NH2:1][C:2]1[C:13]2=[C:14]3[N:9]([CH:10]([CH3:15])[CH2:11][CH2:12]2)[CH:8]=[C:7]([C:16]([OH:18])=[O:17])[C:6](=[O:19])[C:5]3=[CH:4][C:3]=1[F:20].CO[CH:23]1[CH2:27][CH2:26][CH:25](OC)O1>C(O)(=O)C>[OH2:17].[F:20][C:3]1[CH:4]=[C:5]2[C:14]3[N:9]([CH:8]=[C:7]([C:16]([OH:18])=[O:17])[C:6]2=[O:19])[CH:10]([CH3:15])[CH2:11][CH2:12][C:13]=3[C:2]=1[N:1]1[CH:23]=[CH:27][CH:26]=[CH:25]1

参加物

4

反応物 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 131891281H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 8-amino-9-fluoro-6,7-dihydro-5-methyl-1-oxo-

生成物 1

HCID 70532416HCID 70532416、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a suspension of 1.0 g of 8-amino-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid in 20 ml of warm galcial acetic acid was added 1.0 g 2,5-dimethoxytetrahydrofuran. The mixture was heated at reflux for 30 minutes. The product which precipitated was separated by filtration and washed with water to provide yellowish-white crystals of 6,7-dihydro-9-fluoro-5-methyl-1-oxo-8-(1-pyrryl)-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrate, m.p. 300° C. Analysis: Calculated for C18H15FN2O3.1/3H2O: %C, 65.0; %H, 4.7; %N, 8.4; Found: %C, 64.8; %H, 4.5; %N, 8.4. The structural assignment was confirmed by infrared and nuclear magnetic resonance spectral analyses.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 30 minutes
  3. customThe product which precipitated
  4. customwas separated by filtration
  5. washwashed with water

出典と根拠

ORDレコード
ord-39a70a72e5d649c1b721f29f5c25224c
出典データセット
uspto-grants-1983_09
特許番号
US04404207

反応ノート

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