4D-083 → HCID 14450229、化合物

HRID 1995345ノート

反応式

HRID 1995345 の反応式
[O:1]=[C:2]1[C:7]([C:8]([NH2:10])=O)=[CH:6][C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:4][NH:3]1>C(OC(=O)C)(=O)C>[O:1]=[C:2]1[C:7]([C:8]#[N:10])=[CH:6][C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:4][NH:3]1

参加物

3

反応物 1

HCID 14753284D-083

生成物 1

HCID 14450229HCID 14450229、化合物

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

A mixture of 2,3-dihydro-3-oxo-6-phenyl-4-pyridazinecarboxamide (4.2 g) in 100 ml of acetic anhydride is heated under reflux for 6 hours. The acetic anhydride is removed by distillation and the residue is partitioned between ammonium hydroxide solution and dichloromethane. The dichloromethane layer is separated and concentrated on the rotary evaporator and the residue is recrystallized from ethanol to give 2,3-dihydro-3-oxo-6-phenyl-4-pyridazinecarbonitrile.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 6 hours
  3. customThe acetic anhydride is removed by distillation
  4. customthe residue is partitioned between ammonium hydroxide solution and dichloromethane
  5. customThe dichloromethane layer is separated
  6. concentrationconcentrated on the rotary evaporator
  7. customthe residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-7a7fc8ba17e14d108d5fe0783659d6cf
出典データセット
uspto-grants-1983_09
特許番号
US04404203

反応ノート

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