Ammonia → 2-Amino-4,6-dimethyl-5-phenylpyridine-3-carbonitrile
反応式
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH3:10])[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:4]([CH3:17])[N:3]=1.[NH3:18]>CS(C)=O>[NH2:18][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH3:10])[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:4]([CH3:17])[N:3]=1参加物
4
実験手順
2-Chloro-4,6-dimethyl-5-phenyl-3-pyridinecarbonitrile (8.3 grams) was dissolved in 110 ml DMSO and treated with gaseous NH3 at a temperature of 100°-110° C. After about 66 hours of heating and treatment with NH3, the reaction mixture was cooled and poured into ice water. A solid precipitate formed which was collected, washed with water, and then dried in an oven desicator. The identity of the desired product was confirmed by NMR.
後処理
- temperatureAfter about 66 hours of heating
- customA solid precipitate formed which
- customwas collected
- washwashed with water
- customdried in an oven desicator
出典と根拠
- ORDレコード
- ord-224d8c8c64d44274a7efc9da54bd24f6
- 出典データセット
- uspto-grants-1983_09
- 特許番号
- US04405552
反応ノート
読み込み中…