3,4,5,6-Tetrahydrophthalic anhydride → 5-Amino-2-[p-chlorobenzyloxy]pyridine
反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][N:3]=1.[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][OH:17])=[CH:14][CH:13]=1.[C:20]1(=O)[O:25][C:23](=[O:24])[C:22]2[CH2:26][CH2:27][CH2:28][CH2:29][C:21]1=2>>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([O:17][CH2:16][C:15]2[CH:18]=[CH:19][C:12]([Cl:11])=[CH:13][CH:14]=2)=[N:3][CH:4]=1.[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][O:17][C:2]2[CH:7]=[CH:6][C:5]([N:8]3[C:23](=[O:24])[C:22]4[CH2:26][CH2:27][CH2:28][CH2:29][C:21]=4[C:20]3=[O:25])=[CH:4][N:3]=2)=[CH:14][CH:13]=1参加物
5
実験手順
The compound, 5-amino-2-(4-chlorobenzyloxy)pyridine is prepared from 2-chloro-5-nitropyridine and 4-chlorobenzyl alcohol and then reacted with 3,4,5,6-tetrahydrophthalic anhydride using the procedure of Example 1 to yield N-[2-(4-chlorobenzyloxy)-5-pyridyl]-3,4,5,6-tetrahydrophthalimide.