5-[(4-Chlorophenyl)methoxy]-2-nitropyridine → 5-[(4-Chlorophenyl)methoxy]pyridin-2-amine

HRID 1995839ノート

反応式

HRID 1995839 の反応式
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][O:7][C:8]2[CH:9]=[CH:10][C:11]([N+:14]([O-])=O)=[N:12][CH:13]=2)=[CH:4][CH:3]=1>O.CO>[NH2:14][C:11]1[CH:10]=[CH:9][C:8]([O:7][CH2:6][C:5]2[CH:17]=[CH:18][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:13][N:12]=1

参加物

4

反応物 1

HCID 204861295-[(4-Chlorophenyl)methoxy]-2-nitropyridine

生成物 1

HCID 204861125-[(4-Chlorophenyl)methoxy]pyridin-2-amine

試薬・触媒・溶媒 2

HCID 962Water触媒HCID 887Methanol溶媒2 回

実験手順

A mixture of 5-(4-chlorobenzyloxy)-2-nitropyridine (0.5 g), Na2S (0.25 g) and methanol (12 ml) is heated to reflux for about 3 hours. Then, a few drops of water is added and refluxing continued about 15 hours. After cooling, the reaction is diluted with methanol, filtered through celite and stripped. The concentrate is taken up in CHCl3, washed with water, dried and stripped giving 2-amino-5-(4-chlorobenzyloxy)pyridine.

後処理

  1. temperatureis heated
  2. temperatureto reflux for about 3 hours
  3. temperaturerefluxing
  4. temperatureAfter cooling
  5. filtrationfiltered through celite
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-d0b88793ae6c414990b04c5246241a74
出典データセット
uspto-grants-1983_09
特許番号
US04406689

反応ノート

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