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1-Hydroxybenzotriazole → 4-Benzyloxy-3-methoxy-N-(3-benzyloxy-4-methoxyphenyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | 4-(Benzyloxy)-3-methoxybenzoic acid | HCID 226335 | — |
| 反応物 | 3-(Benzyloxy)-4-methoxyaniline | HCID 12547722 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Benzyloxy-3-methoxy-N-(3-benzyloxy-4-methoxyphenyl)benzamide | HCID 59347087 | 71% |
反応手順
N,N-1,3-Diisopropyl carbodiimide (0.40 g, 3.36 mmol) was added to a solution of 1-benzyloxy-2-methoxy-5-aminobenzene (0.771 g, 3.36 mmol), 4-benzyloxy-3-methoxy benzoic acid (0.87 g, 3.36 mmol) and 1-hydroxybenzotriazole (0.454 g, 3.36 mmol) in N,N-dimethylformamide (15 ml) and stirred for 12 hrs. The product was precipitated by diluting with a mixture of ethyl acetate/hexane (1:1) (120 ml). Filtration of the reaction mixture provided 1.12 g of 4-Benzyloxy-3-methoxy-N-(3-benzyloxy-4-methoxyphenyl)benzamide. Yield 69%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745490B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-ab681303a53545a78fbd4db244964824 |
| 出典メモ | uspto-grants-2010_06 |