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Water → 2-Methylpropane-1,3-diyl bis(4-methylbenzenesulfonate)
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 反応物 | Methylpropanediol | HCID 75103 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2-Methylpropane-1,3-diyl bis(4-methylbenzenesulfonate) | HCID 12650468 | — |
反応手順
2-Methylpropane-1,3-diol (50 g, 555 mmol) was dissolved in 555 ml pyridine and cooled to 0° C. p-Toluenesulfonyl chloride (212 g, 1110 mmol) was added and stirring was continued over night. 200 ml H2O was added and the reaction was extracted with DCM (2×1L). The combined organic extracts were dried over MgSO4 and evaporated. The product was recrystallized from EtOH/Hex and the product was obtained as a white solid. MS m/z: 399.0 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745484B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-7d87b2b100184cfc8cc1e9b3684f503c |
| 出典メモ | uspto-grants-2010_06 |