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Sodium cyanoborohydride → 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanone | HCID 11446818 | — |
| 触媒 | zinc(II)iodide | HCID 9883512 | — |
| 溶媒 | 1,1-Dichloroethane | HCID 6365 | — |
| 生成物 | 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol | HCID 11286977 | — |
反応手順
To a solution of 2,2,2-trifluoro-1-(4-hydroxyphenyl)ethanone (5.0 g, 26 mmol) in dichloroethane was added zinc iodide (2.7 ml, 39 mmol) followed by sodium cyanoborohydride (10 ml, 197 mmol). The reaction was stirred at RT for 18 h. Both TLC and LCMS showed one product was formed. MS+=175 (desired mass 192—OH). The mixture was filtered through celite and rinsed with dichloromethane. The filtrate was concentrated and dried in vacuum to afford the title compound as colorless oil. MS m/z: 175(M−H2O).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745484B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-ee744732b1db40f2af28ba7e8613f7fa |
| 出典メモ | uspto-grants-2010_06 |