Hydrochloric Acid → 7-Piperidin-4-yl-7,9-dihydro-8H-purin-8-one hydrochloride

HRID 20082ノート

反応式

HRID 20082 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[N:18][CH:19]=[N:20][CH:21]=3)[NH:16][C:15]2=[O:23])[CH2:10][CH2:9]1)C1C=CC=CC=1.[ClH:24]>O1CCOCC1>[ClH:24].[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[N:18][CH:19]=[N:20][CH:21]=3)[NH:16][C:15]2=[O:23])[CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 222932617-(1-benzylpiperidin-4-yl)-7,9-dihydro-8H-purin-8-one

生成物 1

HCID 222931977-Piperidin-4-yl-7,9-dihydro-8H-purin-8-one hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 7-(1-benzylpiperidin-4-yl)-7,9-dihydro-8H-purin-8-one (1.2 g, 3.7 mmol) in 4N hydrogen chloride in dioxane (50 mL), was stirred vigorously at room temperature for 3 h. The reaction was concentrated in vacuo to give the title compound as a white solid. MS 220 (M+1)

後処理

  1. concentrationThe reaction was concentrated in vacuo

出典と根拠

ORDレコード
ord-07a02e9290584188a460d0f059dad5a2
出典データセット
uspto-grants-2010_06
特許番号
US07745427B2

反応ノート

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