2-Amino-6-methoxy-3-nitropyridine → 2,3-Diamino-6-methoxypyridine
反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1>CO.C(O)C>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1参加物
3
実験手順
2-Amino-6-methoxy-3-nitropyridine (2.8 g, 16.5 mmol) was dissolved in warm 1:1 methanol/ethanol (200 mL). The solution was cooled, purged with argon, and 10% palladium on carbon was added (0.45 g). Hydrogen was introduced (1 atm) and the reaction stirred until complete. The catalyst was filtered and the solvent evaporated from the filtrate to give the title compound. MS 140 (M+1) 1H NMR (500 MHz, CDCl3) δ 6.93 (d, J=8 Hz, 1H), 6.04 (d, J=8 Hz, 1H), 4.15 (br s, 2H), 3.80 (s, 3H), 3.0 (br s, 2H).
後処理
- temperatureThe solution was cooled
- custompurged with argon, and 10% palladium on carbon
- additionwas added (0.45 g)
- additionHydrogen was introduced (1 atm)
- filtrationThe catalyst was filtered
- customthe solvent evaporated from the filtrate
出典と根拠
- ORDレコード
- ord-393a1293af5f45da8e86eb6e83af40c9
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745427B2
反応ノート
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