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3,4-dihydro-2H-pyran → Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 反応物 | Diethyl 5-hydroxypentylphosphonate | HCID 10680635 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate | HCID 19689209 | — |
反応手順
A solution of 66.9 g (0.298 mol) of diethyl 5-hydroxypentylphosphonate, 32.6 g (0.38 mol) of 3,4-dihydropyran and 1 g (0.004 mol) of pyridinium toluene-4-sulfonate in 800 ml of dichloromethane was heated under reflux for 16 hours. The solution was washed with water and saturated sodium hydrogen carbonate solution, dried over sodium sulfate and distilled in a bulb tube.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728686 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-1e24e4dd0b0641159e1602ba6f4a336e |
| 出典メモ | uspto-grants-1998_03 |