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Ethanol → Diethyl 5-hydroxy-1,1-dimethylpentylphosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 反応物 | Diethyl 1,1-dimethyl-5-(tetrahydropyran-2-yloxy)-5-pentylphosphonate | HCID 19689172 | — |
| 生成物 | Diethyl 5-hydroxy-1,1-dimethylpentylphosphonate | HCID 19689221 | — |
反応手順
19.9 g (0.052 mol) of diethyl 1,1-dimethyl-5-(tetrahydropyran-2-yloxy)-5-pentylphosphonate were stirred at 55° C. for 8 hours with 1.5 g (0.006 mol) of pyridinium toluene-4-sulfonate in 200 ml of aqueous ethanol. The solvent was evaporated, the residue was taken up in ethyl acetate, the solution was filtered through a silica gel column and, after evaporating the solvent, the residue was distilled in a bulb tube.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728686 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-73eb847fa4744d04af4bf241c54b60cc |
| 出典メモ | uspto-grants-1998_03 |