関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 7-Benzyl-3-methylxanthine | HCID 685630 | — |
| 反応物 | Diethyl(4-chlorobutyl)phosphonate | HCID 19689195 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate | HCID 22446297 | — |
反応手順
20.4 g (0.08 mol) of 7-benzyl-3-methylxanthine were suspended in 200 ml of dimethylformamide (DMF), treated with 22 g (0.96 mol) of diethyl 4-chlorobutanephosphonate and 13.8 g (0.1 mol) of activated potassium carbonate and heated at 70° C. for 4 hours and filtered, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05728686 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-7a6debe642dd4a55a17f79ac83e9ef86 |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
