Acetamide → Acetamidoglycolic acid
反応式
[C:1]([NH2:4])(=[O:3])[CH3:2].[C:5]([OH:9])(=[O:8])[CH:6]=[O:7]>CC(C)=O>[C:1]([NH:4][CH:6]([OH:7])[C:5]([OH:9])=[O:8])(=[O:3])[CH3:2]参加物
4
実験手順
A mixture of commercially available acetamide 34 and glyoxylic acid 41 was heated at reflux in acetone to give pure N-acetyl-2-hydroxyglycine 42 as a viscous yellow oil in quantitative yield. The 1H n.m.r. spectrum supported formation of the α-hydroxyglycine derivative 42 with the appearance of a methine (H2) doublet and broad amide (NH) doublet at δ 5.39 and δ 8.65 respectively. Spectroscopic data were in agreement with those reported in the literature.195
後処理
- temperaturewas heated
出典と根拠
- ORDレコード
- ord-e76f8a57f7894eaca8797727c758d1d0
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745573B2
反応ノート
読み込み中…