関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Diethyl [4-(3-methylxanthin-1-yl)butyl]phosphonate | HCID 22446315 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Diethyl [4-(7-ethyl-3-methylxanthin-1-yl)butyl]phosphonate | HCID 22446294 | — |
反応手順
7.2 g (0.02 mol) of diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate were suspended in 100 ml of DMF, treated with 4.7 g (0.03 mol) of ethyl iodide and 4.1 g (0.03 mol) of activated potassium carbonate and heated at 60° C. for 4 hours. The solid was filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05728686 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-056956b73b9f45e9955998f708e34b9b |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
