化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → Benzyl 4-((3-methoxy-3-oxopropyl)amino)piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Benzyl 4-oxopiperidine-1-carboxylate | HCID 643496 | — |
| 反応物 | Methyl 3-aminopropanoate hydrochloride | HCID 2734767 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 溶媒 | 1,1-Dichloroethane | HCID 6365 | — |
| 生成物 | Benzyl 4-((3-methoxy-3-oxopropyl)amino)piperidine-1-carboxylate | HCID 68419530 | 87.4% |
反応手順
A solution of benzyl 4-oxopiperidin-1-carboxylate (10 g), β-alanine methyl ester monohydrochloride (5.99 g), acetic acid (4 mL) and sodium triacetoxyborohydride (10.9 g) in dichloroethane (400 mL) was stirred overnight. The reaction mixture was washed with aqueous saturated sodium bicarbonate solution and saturated saline solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the title compound (12.0 g, 87%) as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745623B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-de45e883b33e49fb877442f2ee862f0f |
| 出典メモ | uspto-grants-2010_06 |