4-Chlorophenyl isothiocyanate → N-(4-chlorophenyl)-3-methylpiperazine-1-carbothioamide

HRID 20275

反応式

HRID 20275 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[S:10])=[CH:4][CH:3]=1.[CH3:11][CH:12]1[CH2:17][NH:16][CH2:15][CH2:14][NH:13]1>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([N:16]2[CH2:15][CH2:14][NH:13][CH:12]([CH3:11])[CH2:17]2)=[S:10])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 164804-Chlorophenyl isothiocyanateHCID 660572-Methylpiperazine

生成物 1

HCID 59347497N-(4-chlorophenyl)-3-methylpiperazine-1-carbothioamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 4-chlorophenyl isothiocyanate (8.0 g, 47.17 mmol) in dichloromethane (250 mL) was added dropwise over 30 minutes to an ice cooled solution of 2-methylpiperazine (9.45 g, 94.33 mmol) in dichloromethane (250 mL). Once the addition was complete, the reaction was stirred at room temperature for an hour. The reaction was then washed with water (3×), dried over MgSO4 and concentrated under reduced pressure, to give the title compound as a white solid, 11.8 g.

後処理

  1. additionOnce the addition
  2. washThe reaction was then washed with water (3×)
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-5f9a14faca964707886135ffa8096e54
出典データセット
uspto-grants-2010_06
特許番号
US07745630B2

関連ノート

読み込み中…