Triethylamine → N-(4-chlorophenyl)-4-cyano-4-phenylpiperidine-1-carbothioamide

HRID 20277

反応式

HRID 20277 の反応式
C(N(CC)CC)C.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]=[C:16]=[S:17])=[CH:11][CH:10]=1.Cl.[C:19]([C:21]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)#[N:20]>ClCCl>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([N:24]2[CH2:25][CH2:26][C:21]([C:19]#[N:20])([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:22][CH2:23]2)=[S:17])=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 164804-Chlorophenyl isothiocyanateHCID 30849734-Phenylpiperidine-4-carbonitrile hydrochloride

生成物 1

HCID 3875011N-(4-chlorophenyl)-4-cyano-4-phenylpiperidine-1-carbothioamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Triethylamine (1.4 mL, 10 mmol) was added to a suspension of 4-chlorophenyl isothiocyanate (1.69 g, 10 mmol) and 4-cyano-4-phenylpiperidine hydrochloride (2.22 g, 10 mmol) in dichloromethane (100 mL), and the reaction was then stirred at room temperature for 20 minutes. The mixture was washed with 2N hydrochloric acid, then brine, it was dried over MgSO4 and evaporated under reduced pressure to afford the title compound as a white solid, 3.62 g.

後処理

  1. washThe mixture was washed with 2N hydrochloric acid
  2. dry with materialbrine, it was dried over MgSO4
  3. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-e59ae674d51d457999a3180b2ce91eb5
出典データセット
uspto-grants-2010_06
特許番号
US07745630B2

関連ノート

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