4-Chloro-2-fluoro-1-nitrobenzene → 4-Chloro-2-ethoxy-1-nitrobenzene
反応式
[O-:1][CH2:2][CH3:3].[Na+].[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8](F)[CH:7]=1>C(O)C>[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]([O:1][CH2:2][CH3:3])[CH:7]=1参加物
4
実験手順
Sodium ethoxide (21% in ethanol, 8.6 mL, 26 mmol) was added dropwise to a solution of 4-chloro-2-fluoronitrobenzene (3 g, 17.1 mmol) in ethanol (20 mL), and once addition was complete the reaction was stirred for a further hour. The mixture was concentrated under reduced pressure, the residue was diluted with ethyl acetate, and the solution was washed with water (×2), then brine. The solution was dried over MgSO4 and evaporated under reduced pressure to afford the title compound as a solid, 3.45 g.
後処理
- concentrationThe mixture was concentrated under reduced pressure
- additionthe residue was diluted with ethyl acetate
- washthe solution was washed with water (×2)
- dry with materialThe solution was dried over MgSO4
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-5c02991cfdbf4549af3c25a0e2d8ad88
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745630B2
反応ノート
読み込み中…