関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Bromopropane | HCID 7840 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1H-Purine-2,6-dione, 3,7-dihydro-3-cyclopropyl- | HCID 3058996 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-Cyclopropyl-7-propylxanthine | HCID 19689270 | — |
反応手順
9.6 g (0.05 mol) of 3-cyclopropylxanthine were suspended in 150 ml of dimethylformamide and slowly deprotonated using 1.45 g (0.06 mol) of sodium hydride. When evolution of hydrogen was at an end, the solution was heated to 60° C. and treated dropwise with 6.77 g (0.055 mol) of bromopropane. After stirring at 70° C. for 3 hours, the solution was filtered, the dimethylformamide was evaporated under reduced pressure and the residue was crystallized from diisopropyl ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05728686 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-8e167d88150f459d95e6145c9ec1c182 |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
