化工社化工社 化学情報印刷レポート · 研究参考用
Nitromethane → 1-(3,5-Difluorophenyl)-2-nitroethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitromethane | HCID 6375 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3,5-Difluorobenzaldehyde | HCID 588160 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(3,5-Difluorophenyl)-2-nitroethanol | HCID 68562553 | — |
反応手順
Add nitromethane (200 mL) to a suspension of potassium carbonate (30 g) and 3,5-difluorobenzaldehyde (200 g) in tetrahydrofuran (600 mL) at room temperature. Stir at room temperature overnight, filter, wash with ethyl acetate and concentrate to give the desired compound as a crude oil (330 g) which is used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745438B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-2cf9865e0403426b8bcade080e174cea |
| 出典メモ | uspto-grants-2010_06 |