関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Bromo-3-methylbutane | HCID 7891 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-Methylxanthine | HCID 70639 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-(3-Methylbutyl)-3-methylxanthine | HCID 19689144 | — |
反応手順
100 g (0.602 mol) of 3-methylxanthine, dissolved in 1200 ml of DMF, were slowly treated with 16 g (0.66 mol) of sodium hydride. The solution was heated to 60° C. and, when the evolution of hydrogen was at an end, treated with 109 g (0.66 mol) of 1-bromo-3-methylbutane. The reaction mixture was stirred at 100° C. for 12 hours and introduced into 2000 ml of water. The precipitate was filtered off with suction, washed with water and dried to constant weight.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05728686 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-53dbbec3515e46f1bf52497ce7ab8115 |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
