8-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine → 8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine

HRID 2035426ノート

反応式

HRID 2035426 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][NH:9][CH2:8][CH:7]([CH3:12])[C:6]=2[CH:13]=1.IC1C=CC2CCNCC(C)C=2C=1.FC(F)(F)C1C=CC2CCNCC(C)C=2C=1.FC(F)(F)C1C=CC2CCNCC(CC)C=2C=1.[Cl:60]C1C=CC2CCNCC(CC)C=2C=1.BrC1C=CC2CCNCC(CC)C=2C=1.IC1C=CC2CCNCC(CC)C=2C=1.ClC1C(Cl)=CC2C(C)CNCCC=2C=1.ClC1C(Cl)=CC2C(CC)CNCCC=2C=1.ClC1C(F)=CC2CCNCC(C)C=2C=1.ClC1C(F)=CC2CCNCC(CC)C=2C=1>>[Cl:60][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][NH:9][CH2:8][CH:7]([CH3:12])[C:6]=2[CH:13]=1

参加物

12

反応物 11

HCID 99908088-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 99914447,8-Dichloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 100824778-Chloro-7-fluoro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 101052081-Methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 102422038-Chloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 102434968-Trifluoromethyl-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 102638397,8-Dichloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 103318418-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 103801018-Iodo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 10467471HCID 10467471、化合物HCID 117787918-Iodo-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

生成物 1

HCID 104652638-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine

実験手順

8Bromo-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Iodo-1methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Trifluoromethyl-1-methyl-2,3,4,5-tetrahydro-1H-3benzazepine; 8-Trifluoromethyl-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8Chloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Bromo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Iodo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 7,8-Dichloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 7,8-Dichloro-1-ethyl-2,3,4,5tetrahydro-1H-3-benzazepine; 8-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; and 8-Chloro-7-fluoro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; or a pharmaceutically acceptable salt, solvate or hydrate thereof.

出典と根拠

ORDレコード
ord-a933917cdaf94e6a93144403fa5cbd45
出典データセット
uspto-grants-2013_11
特許番号
US08575149B2

反応ノート

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