6-[4-Methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester → HCID 67412646、化合物

HRID 2035547ノート

反応式

HRID 2035547 の反応式
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([N:19]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=2)[C:20]2[CH:21]=[N:22][C:23]([N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[CH:24][CH:25]=2)=[CH:10][C:11]=1[NH:12]C(=O)C(F)(F)F)=[O:5])[CH3:2]>CO.C(=O)([O-])[O-].[K+].[K+].O>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([N:19]([CH2:32][C:33]2[CH:34]=[CH:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=2)[C:20]2[CH:21]=[N:22][C:23]([N:26]3[CH2:27][CH2:28][O:29][CH2:30][CH2:31]3)=[CH:24][CH:25]=2)=[CH:10][C:11]=1[NH2:12])=[O:5])[CH3:2]

参加物

5

反応物 1

HCID 866579436-[4-Methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester

生成物 1

HCID 67412646HCID 67412646、化合物収率 100%

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒2 回HCID 11430Potassium Carbonate溶媒

実験手順

51 mg of 6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester was dissolved in 5 mL of methanol, to which 3 mL of 2 mol/L potassium carbonate in water was added, and stirred at room temperature for 4 hours. To the reaction mixture water was added, extracted with ethyl acetate, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated to obtain 42 mg (yield 100%) of the title compound as a light yellow solid.

後処理

  1. additionwas added
  2. extractionextracted with ethyl acetate
  3. washthe extract was washed with saturated saline
  4. dry with materialdried on anhydrous sodium sulfate
  5. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-9ee59c8823ed4d239c60dcbdef661608
出典データセット
uspto-grants-2013_11
特許番号
US08575153B2

反応ノート

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