2-Hydrazinyl-4-methylpyridine → N-[(E)-[8-[tert-butyl(dimethyl)silyl]oxyquinolin-2-yl]methylideneamino]-4-methylpyridin-2-amine

HRID 2035628ノート

反応式

HRID 2035628 の反応式
[NH:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][N:4]=1)[NH2:2].[Si:10]([O:17][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:27]=1[N:26]=[C:25]([CH:28]=O)[CH:24]=[CH:23]2)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:12])[CH3:11]>CCO>[Si:10]([O:17][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:27]=1[N:26]=[C:25](/[CH:28]=[N:2]/[NH:1][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][N:4]=1)[CH:24]=[CH:23]2)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:11])[CH3:12]

参加物

4

反応物 2

HCID 122667392-Hydrazinyl-4-methylpyridineHCID 585670828-(Tert-butyldimethylsilyloxy)quinoline-2-carbaldehyde

生成物 1

HCID 67230767N-[(E)-[8-[tert-butyl(dimethyl)silyl]oxyquinolin-2-yl]methylideneamino]-4-methylpyridin-2-amine収率 81%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Hydrazinyl-4-methylpyridine (0.280 g, 2.27 mmol) and 8-(tert-butyldimethylsilyloxy)quinoline-2-carbaldehyde (0.653 g, 2.27 mmol) were suspended in EtOH (6 mL) and stirred overnight at ambient temperature. The resulting suspension was filtered and the solid was washed with cold EtOH and dried in vacuo to provide the title compound (0.720 g; 81%).

後処理

  1. filtrationThe resulting suspension was filtered
  2. washthe solid was washed with cold EtOH
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-a644c984bf624698829627216e52a21a
出典データセット
uspto-grants-2013_11
特許番号
US08575145B2

反応ノート

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