Tetrafluoro-m-phenylenediamine dihydrochloride → 2-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)-8-((trans)-3-fluoropiperidin-4-yloxy)quinoline dihydrochloride

HRID 2035651ノート

反応式

HRID 2035651 の反応式
C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:13].Cl.F[C@H]1[C@H](OC2C=CC=C3C=2N=CC=C3)CCNC1.[N:33]1[N:34]=[C:35]([C:42]2[CH:51]=[CH:50][C:49]3[C:44](=[C:45]([O:52][C@@H:53]4[CH2:58][CH2:57][NH:56][CH2:55][C@H:54]4[F:59])[CH:46]=[CH:47][CH:48]=3)[N:43]=2)[N:36]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=12>O>[ClH:13].[ClH:13].[N:33]1[N:34]=[C:35]([C:42]2[CH:51]=[CH:50][C:49]3[C:44](=[C:45]([O:52][C@@H:53]4[CH2:58][CH2:57][NH:56][CH2:55][C@H:54]4[F:59])[CH:46]=[CH:47][CH:48]=3)[N:43]=2)[N:36]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=12

参加物

5

反応物 3

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 667820318-((trans)-3-Fluoropiperidin-4-yloxy)quinolineHCID 672301232-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)-8-((trans)-3-fluoropiperidin-4-yloxy)quinoline

生成物 1

HCID 672344752-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)-8-((trans)-3-fluoropiperidin-4-yloxy)quinoline dihydrochloride

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Preparation of the dihydrochloride salt of Enantiomer 2 of 2-k [1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-((trans)-3-fluoropiperidin-4-yloxy)quinoline: Prepared as described in Example 94 using non-racemic 2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-((trans)-3-fluoropiperidin-4-yloxy)quinoline in Step 4C. Specific rotation: [α]20D=+2.7° (c=0.45, 1:1 water/95% ethanol).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-992da550797e48229e0b30463ce69240
出典データセット
uspto-grants-2013_11
特許番号
US08575145B2

反応ノート

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