Sulfuric Acid → HCID 86663613、化合物

HRID 2035748ノート

反応式

HRID 2035748 の反応式
[F:1][C:2]1([F:16])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]#[N:13])=[CH:11][C:5]=2[O:4][C:3]1([F:15])[F:14].S(=O)(=O)(O)[OH:18]>O>[F:16][C:2]1([F:1])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]([NH2:13])=[O:18])=[CH:11][C:5]=2[O:4][C:3]1([F:14])[F:15]

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 27766192,2,3,3-Tetrafluoro-1,4-benzodioxane-6-carbonitrile

生成物 1

HCID 86663613HCID 86663613、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
40 °C

実験手順

To 2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxine-6-carbonitrile (200 mg) were added concentrated sulfuric acid (2 mL) and water (0.3 mL) at room temperature. The reaction mixture was stirred at 40° C. for 3 hr, water was added and the mixture was stirred for 40 min at room temperature. The resulting solid was collected by filtration, washed with purified water, and dried under reduced pressure to give the title compound (190.6 mg).

後処理

  1. stirringthe mixture was stirred for 40 min at room temperature
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with purified water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-a2994967f4564fc18f8c4f408afcdb76
出典データセット
uspto-grants-2013_11
特許番号
US08575154B2

反応ノート

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