(R)-3-fluoro-4-(7-oxo-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)benzonitrile → 4-((5R)-8-(4-fluorophenyl)-8-hydroxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

HRID 2036035

反応式

HRID 2036035 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[C@@H]1N2C=NC=C2C(=O)C1)C#N.[O:19]=[C:20]1[CH2:25][CH2:24][C@H:23]([C:26]2[CH:33]=[CH:32][C:29]([C:30]#[N:31])=[CH:28][CH:27]=2)[N:22]2[CH:34]=[N:35][CH:36]=[C:21]12>>[F:1][C:2]1[CH:3]=[CH:4][C:7]([C:20]2([OH:19])[CH2:25][CH2:24][C@H:23]([C:26]3[CH:33]=[CH:32][C:29]([C:30]#[N:31])=[CH:28][CH:27]=3)[N:22]3[CH:34]=[N:35][CH:36]=[C:21]23)=[CH:8][CH:9]=1

参加物

3

反応物 2

HCID 67216150(R)-3-fluoro-4-(7-oxo-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)benzonitrileHCID 67216373(R)-4-(8-oxo-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

生成物 1

HCID 532371184-((5R)-8-(4-fluorophenyl)-8-hydroxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

実験手順

Following compounds are prepared using similar procedure as example 1-1 through example 1-7 using either 3-fluoro-4-((R)-7-oxo-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-benzonitrile or (R)-4-(8-oxo-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile with appropriate reagents and conditions: Note when possible, separation of diastereomers were individually achieved with preparation plates, flash chromatography, prep-LCMS, HPLC, and or using HPLC CHIRALPAK® HPLC columns (such as AD, OJ, OD, etc.) which are purchased from Daicel.

後処理

  1. customare prepared
  2. customseparation of diastereomers
  3. customwere individually achieved with preparation plates, flash chromatography

出典と根拠

ORDレコード
ord-de47e83f1843440aa1e8bd0b8009ccfc
出典データセット
uspto-grants-2013_11
特許番号
US08575160B2

関連ノート

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