HCID 335465、化合物 → 1'H-Spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one
反応式
C([N:8]1[CH2:23][CH2:22][C:11]2([NH:20][C:19](=[O:21])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[NH:12]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[C].[Pd]>[NH:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:19](=[O:21])[NH:20][C:11]21[CH2:22][CH2:23][NH:8][CH2:9][CH2:10]2参加物
4
実験手順
1-Benzyl-1′H-spiro[piperidine-4,2′-quinazolin]-4′ (3′H)-one (5.0 g) and 10% palladium-carbon (500 mg) were suspended in methanol (200 mL), and the suspension was stirred at room temperature for 2 days under a hydrogen atmosphere. The catalyst was removed by filtration through celite. The solvent was evaporated under reduced pressure and the residue was crystallized from ethanol/ether to give the object product (2.34 g, 41%).
後処理
- customThe catalyst was removed by filtration through celite
- customThe solvent was evaporated under reduced pressure
- customthe residue was crystallized from ethanol/ether
出典と根拠
- ORDレコード
- ord-40a30727816c4c00b2bd0abfa34195d7
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08575167B2
反応ノート
読み込み中…