Potassium Carbonate → 1'-(6-Phenylpyridazin-3-yl)spiro[indene-1,4'-piperidine]
反応式
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.FC(F)(F)C(O)=O.[NH:21]1[CH2:26][CH2:25][C:24]2([C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=[CH:27]2)[CH2:23][CH2:22]1.C(=O)([O-])[O-].[K+].[K+]>>[C:8]1([C:5]2[N:4]=[N:3][C:2]([N:21]3[CH2:26][CH2:25][C:24]4([C:34]5[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=5)[CH:28]=[CH:27]4)[CH2:23][CH2:22]3)=[CH:7][CH:6]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1参加物
4
実験手順
The object product (54 mg, 27%) was obtained in the same manner as in Example 1 and using 3-chloro-6-phenylpyridazine (114 mg), spiro[indene-1,4′-piperidine] trifluoroacetate (210 mg) and potassium carbonate (130 mg).
出典と根拠
- ORDレコード
- ord-dde63e8f59564434a77809e5d6597c0a
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08575167B2
反応ノート
読み込み中…