Spiro[chromene-2,3'-pyrrolidine] hydrochloride → 1047656-03-0
反応式
[ClH:1].[NH:2]1[CH2:6][CH2:5][C:4]2([CH:15]=[CH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[O:7]2)[CH2:3]1>CO.[C].[Pd]>[ClH:1].[NH:2]1[CH2:6][CH2:5][C:4]2([CH2:15][CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[O:7]2)[CH2:3]1参加物
4
実験手順
Spiro[chromene-2,3′-pyrrolidine] hydrochloride (150 mg) synthesized in Example 33(1) and 5% palladium-carbon (30 mg) were suspended in methanol (10 mL), and the suspension was stirred overnight under a hydrogen atmosphere at room temperature. The catalyst was removed by filtration through celite, and the solvent was evaporated under reduced pressure to give the object product (130 mg, 86%).
後処理
- customThe catalyst was removed by filtration through celite
- customthe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-d62175440f334cfb87d01dd88cc4f2aa
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08575167B2
反応ノート
読み込み中…