Phthalimide → HCID 58459111、化合物

HRID 2036561ノート

反応式

HRID 2036561 の反応式
[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([Cl:11])[C:5]2=[N:4][C:3]=1[CH2:12]Cl.[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([Cl:11])[C:5]2=[N:4][C:3]=1[CH2:12][N:18]1[C:14](=[O:24])[C:15]2[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:17]1=[O:19]

参加物

5

反応物 3

HCID 6809PhthalimideHCID 11430Potassium CarbonateHCID 58459174HCID 58459174、化合物

生成物 1

HCID 58459111HCID 58459111、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

DMF (4.6 ml) was added to a mixture of 3-bromo-8-chloro-2-(chloromethyl)imidazo[1,2-a]pyridine (258 mg, 0.922 mmol), phthalimide (136 mg, 0.922 mmol) and K2CO3 (55.6 μL, 0.922 mmol). The reaction was heated at 80° C. After the reaction was complete, the mixture was initially partitioned between EtOAc and water, but the product did not dissolve readily. The product was collected by filteration of the mixture to give 2-((3-bromo-8-chloroimidazo[1,2-a]pyridin-2-yl)methyl)isoindoline-1,3-dione as a white solid.

後処理

  1. customthe mixture was initially partitioned between EtOAc and water
  2. dissolutionthe product did not dissolve readily
  3. customThe product was collected by filteration of the mixture

出典と根拠

ORDレコード
ord-b6227c1a9e044234b09e621056089cf0
出典データセット
uspto-grants-2013_11
特許番号
US08575183B2

反応ノート

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