Hydrochloric Acid → 2-(Cyclobutylcarbonyl)-N-hydroxy-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
反応式
[CH:1]1([C:5]([N:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:17]([NH:19][O:20]C4CCCCO4)=[O:18])[CH:13]=3)[CH2:8]2)=[O:6])[CH2:4][CH2:3][CH2:2]1.Cl>O.CO>[CH:1]1([C:5]([N:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:17]([NH:19][OH:20])=[O:18])[CH:13]=3)[CH2:8]2)=[O:6])[CH2:2][CH2:3][CH2:4]1参加物
5
実験手順
160 mg of 2-(cyclobutylcarbonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide and 2 ml of a 0.1M solution of HCl in water in 2 ml methanol are stirred overnight at ambient temperature. The reaction mixture is evaporated and the residue is treated with acetonitrile. 53 mg of nearly colorless crystals are obtained. MH+=275.1